If that's the case, the Cardinals could pull off the upset. Matchup rating: 42.5 | Spread: MIN -5.5 (43.5), What to watch for: How will Kirk Cousins perform vs. the Giants' 25th-ranked pass defense, which is allowing 279.5 yards per game. Cowboys 27, Packers 23 -- Rob Demovsky, For the second consecutive week, the Cowboys are facing a team with a 10-day break. McClure's pick: Texans 24, Falcons 21 -- Josh Weinfuss, Bold prediction: Arizona will double its sack total on the season and take Jalen Hurts down four times. Matchup rating: 44.9 | Spread: CHI -5 (40.5), What to watch for: Khalil Mack will be looking to take over the game against his former teammates. -- Todd Archer, Bold prediction: The first team to 30 rushing attempts will win. Swift likely out again vs. Patriots, source says, What to watch for: The Vikings' defense has given up 1,054 passing yards this season, seventh-most in the NFL, as it meanders through the adjustment process to coordinator Ed Donatell's 3-4 scheme. Watch on ESPN+ More , Bold prediction: Nope. What to know for fantasy: Pierce has more than 100 scrimmage yards and a rushing score in consecutive games. And the Washington passing attack? 125 attempts). ET | CBS Meanwhile, the Cowboys are tied for second in the league with 15 sacks and own the best pass rush win rate in the NFL (56.3%), according to ESPN Metrics powered by NFL Next Gen Stats. But this will be an emotional weekend at Lucas Oil Stadium for the Colts. -- Ben Baby. Expect the Raiders' overachieving defense to make a play or two -- paging Khalil Mack and his four sacks -- to jump-start the offense, and all will be right in Silver and Blackdom for a week, at least. Indianapolis' offensive efficiency might be a good match for Kansas City's offensive power. What to know for fantasy: Austin Ekeler scored more fantasy points last week in Houston (34.9) than he did in the two weeks prior combined (31.7). They'll do just enough to keep things that way. The good news for the Cowboys is that even after another ignominious loss dropped them to 1-3, they're still only a half-game out of first place in the NFC East, the only division with . The Bucs also gave up an uncharacteristic 189 rushing yards in their 41-31 loss to the Kansas City Chiefs last week -- the most they've surrendered since 2018. Louis-Jacques' pick: Bills 14, Titans 10 The Chiefs' offense is a complete running and passing groove with Patrick Mahomes. Through four games, they have collected an NFL-low 390 passing yards -- the fourth fewest by any team at this point in a season since 2000. Steelers' first draft by Khan 'aggressive' -- Jeff Legwold. NFL Nation reporters give their picks for Week 5, including whether the Cowboys can bounce back against Aaron Rodgers and the Packers. -- Brady Henderson. He is the first player with nine sacks through the first four games of a season since Kabeer Gbaja-Biamila recorded nine in 2001. Walder's pick: Rams 27, Cowboys 17 The Vikings' passing game has been bad (169.0 yards per game), prompting receiver Adam Thielen to express his frustrations and, in turn, Cousins to apologize. And regardless of whos at quarterback, Adam Thielen and Stefon Diggs need to spark the Vikings' aerial attack early while the running game gets in its groove with Latavius Murray taking the reins for an injured Dalvin Cook. Plus, Antonio Brown is angry and wants the ball, which means he's due for a big game. The Vikings sacked Lions quarterback Matthew Stafford six times in a losing effort last week. Even at full strength, Seattle's offensive line will have its hands full against a Rams front four that has given the Seahawks all sorts of trouble during the past few seasons. Stat to know: Chargers receiver Keenan Allen leads the NFL with 452 receiving yards, and he is the only player with more than 400. Elliott is coming off the third-fewest rushing yards of his career, yet the Packers are allowing 142.3 yards per game and 5.0 yards per carry. For the season on third downs, he's completing only 48.9% of his passes and owns a 78.0 passer rating. All-Time Longhorns NFL Draft Picks. LAC-CLE | SEA-NO | TEN-WSH 3 all-time rusher Barry Sanders, Meet Brady's most trusted teammate: His 1995 shoulder pads, Redskins' January decision to maintain status quo looks bad in hindsight, Patriots' offense searching for identity, as it did in 2018, Big pass plays tearing up Ravens' defense, 'Do whatever' to win: Steelers bring back the Wildcat, Raiders hoping to reverse London trend by changing travel schedule, Left with no defense, Jackson needs to carry Ravens this season, Steelers' first draft by Khan 'aggressive', Mack expected to be with the Raiders 'for the long haul', Daniel embraces seldom-used, uncertain backup QB life, Carr: Burfict's 'heart is broken;' QB says ban isn't fair, Analyzing how, where Golden Tate fits into Giants' offense. But this week, players and coaches have been quick to say that was one game and the Chiefs present a different challenge. Betting nugget: Baltimore is 12-2-2 ATS when the line is between +3 and -3 since 2019 (Lamar Jackson's first full season as starter). ET | ESPN/ESPN App The Bills aren't known for a traditional ground game, but the Steelers' defense is giving up an average of 131.5 rushing yards per game. What to know for fantasy: With two games of seven-plus targets already this season, plus a TD reception in Week 4, Bengals tight end Hayden Hurst has potential. Additionally, the Eagles are averaging a league-high 8.79 passing yards per play while the Cardinals are giving up 7.36, which ranks 25th in the league. It's time to look ahead to Week 5. The Colts, like in previous seasons, are struggling statistically on defense, ranking 31st overall. Read more. ET | CBS ET | FOX Spread: NE -3.0 (45.5). Spread: KC -7.0 (51), What to watch for: The Raiders might need to score a big number in order to win. What to know for fantasy: Zach Ertz finished last season as TE2 despite not scoring his first touchdown until Week 5. They also have a good secondary, which already has five interceptions. UPDATE: I made seven changes to my final mock draft -- starting with the No. Stat to know: The Eagles are the only team to win the turnover battle in every game this season. McManus' pick: Steelers 24 . Betting nugget: Over the past five seasons, Miami is 13-7 ATS as a favorite. -- Turron Davenport, Bold prediction: The Bills, who possess the NFL's fourth-best rushing attack in terms of yards per game, will run for at least 150 yards against a Titans defense that has given up a combined 146 rushing yards over its past two games. He has also been sacked 11 times, tied for the eighth most in the NFL. The Steelers' 2022 quarterback journey, and what happens next, What to watch for: The Patriots have given up 325 rushing yards on 51 carries (6.37 on average) over their past six quarters, while the Lions rank first in the NFL in average yards per rush (5.9) and sixth in total rushing yards per game (164). TB-NO | ATL-HOU | BUF-TEN After catching eight passes for 111 yards in the season opener, he has not reached 70 receiving yards in any of the past three games. Chargers-Saints point spread: Saints -8.0 (over/under 50.0) Jack Driscoll, who hasn't started a game at left tackle since college, has been getting the work on Hurts' blind side this week. Stat to know: Cincinnati's Joe Mixon is averaging a career-low 3.2 yards per rush and 37.3 yards per game this season. Analyzing how, where Golden Tate fits into Giants' offense, 1 p.m. ESPN researcher Kyle Soppe hands out helpful fantasy football intel, as well. Herbert also totaled five touchdowns. Read more. ET | FOX Read more. The Bengals are allowing 8.6 yards per attempt, which is ideal for a team averaging 5.5 despite having Kyler Murray -- who has thrown for 300 yards in two of his first four games. Dolphins 19, Titans 17 -- Cameron Wolfe, The Dolphins allowed 235 rushing yards in last year's loss to the Titans. How have point spreads moved for Week 5 as Sunday approaches? Rodgers hasn't topped 255 yards passing this season, and the Giants have the eighth-ranked pass defense. Stat to know: The Titans have allowed a player to record six or more receptions in each of their four games this season. What to know for fantasy: Murray leads the NFL with 187 opportunities this season (pass-plus-rush attempts). What to know for fantasy: Receiver Sammy Watkins scored 46.8 points in Week 1, but that is 18.1 more fantasy points than he has scored in the three weeks since. The Bears, however, are the league's least-equipped team to exploit that shortcoming. Another big day could be in store for Bosa here, and don't be surprised if he brings back the "flag plant" celebration he used against Mayfield in that previous meeting. ET | CBS Colts 23, 49ers 20 -- Nick Wagoner, The last thing the Colts can do is overlook the 49ers. Trevor Lawrence: Jaguars have confidence, motivation for 2023 season, Steelers work to keep playoff hopes, Mike Tomlin's streak alive, Las Vegas Raiders' defensive tackles key in allowing edge rushers Maxx Crosby, Chandler Jones to thrive, 'He's got all the help he needs': Trey Lance won't have to be savior for loaded San Francisco 49ers, Las Vegas Raiders running backs the 'heartbeat' of the new regime's offensive attack, Mac Jones, Patriots express confidence in 'new offense' despite growing pains, New York Giants likely to buck norm, make safety Xavier McKinney defensive playcaller, Tyquan Thornton shows signs he could end Patriots' early-round WR woes. The versatile back is now on pace for 115 catches this season. Betting nugget: Carolina is 3-15 ATS in its past 18 games. -- Courtney Cronin. Justin Fields is 3-9 ATS as an underdog. Levis opens up about draft day The Bengals can build on their momentum here, and a win would make them 2-3 prior to their bye. If the Jaguars have the same kind of issues along the defensive front they did last week, it'll be another long day. -- Nick Wagoner, Embracing the fun spirit of fantasy sports, ESPN senior fantasy analyst Matthew Berry and his unconventional cast of characters aim to make fantasy football players smarter and help them win their leagues. Colts 21, 49ers 17 -- Mike Wells, Marcus Mariota's playing status could be unknown until Sunday, but the Titans have problems to solve even if he does find a way to play. The last thing the Vikings need is for Diggs' situation to blow up into a full-blown distraction. Given the Colts' struggles protecting the quarterback (they've allowed 14 sacks, tied for fifth most in the league) and the Niners' ability to take advantage of porous offensive lines (nine sacks total against Seattle and Arizona), this would seem to be the type of game the 49ers can win. Game of Midweek: Colts at Broncos (-3.5, 44 o/u) . He's a bad matchup for the Jaguars because they've had issues covering backs out of the backfield. Stat to know: Texans edge rusher Whitney Mercilus now has four straight games with a sack, tied for the longest active streak in the NFL with Clay Matthews and Shaquil Barrett. Victor Cruz contends that Gardner Minshew is better equipped to lead his team to victory in the matchup with Panthers QB Kyle Allen. Read more. See Week 5 rankings. -- Lindsey Thiry. -- Eric Woodyard. Allgeier and Caleb Huntley will handle the majority of the work with Patterson (knee) on injured reserve, and the two young backs will alternate to cause problems for the Buccaneers. Betting nugget: Bridgewater is 25-7 against the spread (ATS) in his career as a starting quarterback, the best mark by any QB with at least 15 starts in the Super Bowl era. Stat to know: The 49ers are 0-2 and averaging 10.0 points per game on the road this season -- and 2-0, 25.5 PPG at home. See Week 5 rankings. Just ask Tampa Bay Buccaneers fans, or Buffalo Bills fans, or Seattle Seahawks fans, or the defense of the Dallas Cowboys.. -- Todd Archer. Meanwhile, Mahomes has thrown two interceptions, and the team has also lost two fumbles through four games. Stat to know: Geno Smith has a 77.3 completion percentage this season, the highest by any QB through a team's first four games of a season in NFL history (min. These two teams just played each other in the regular season finale last week when the Roughnecks won 25-9 despite Brandon Silvers, Max Borghi, Deontay Burnett, and Brycen Alleyne all sitting. Thus, breaking the streak won't be easy for the Ravens. The story of the Cowboys scout and prospect son Dallas just drafted, Legacy pick: Cardinals take great-great-nephew of team's first-ever draft pick, Winston already improving under 'QB whisperer' Bruce Arians, Yes, he's 2-0, but the Saints will need more from Bridgewater, Matthew Berry's Love/Hate for Week 5: How to make a trade, NFL experts predict: Week 5 upset picks, fantasy football flops and sleepers, How Watson's 'NFL experience' began as ball boy for the Falcons, TE Hooper could be the next Falcon to cash in, Taylor Lewan's return could be a boon for Titans' offense, Gore closing on No. But the Commanders' run defense will be severely tested by Tennessee running back Derrick Henry. Panthers 24, Lions 21 -- David Newton, Defending Newton will be tough, and linebacker Luke Kuechly could cause Stafford some issues, but the Lions have shown they are one of the better teams in the NFC. But the key in this one will be the ability of the Carolina defense to make the Lions one-dimensional and force Matthew Stafford to beat them. Finally, Seth Walder and Eric Moody give us final score picks for every game. Theres not a whole lot of tape out there on Trubisky, which is a disadvantage for Minnesota in game planning. Walder's pick: Eagles 23, Cardinals 20 Chicago head coach Matt Nagy is high on veteran backup quarterback Chase Daniel, who's starting in place of Mitchell Trubisky (left shoulder), but Nagy still wants to control the clock and pound the ball with Montgomery.

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